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Table 2 - Locally Acting Medications for Pain Relief
Class Name Chemical name Risks
Medrol Dosepak methylprednisolone GI
Muscle Relaxants
Flexeril cyclobenzaprene DI, DR, CE
Soma carisoprodol DI, DR, A1
Robaxin methocarbamol DI, DR
Skelaxin metaxolone DR, LT
Baclofen lioresal DI, DR, WI
Parafon Forte chlorazoxazone LT, A1
Valium diazepam A1, MC, DI, DR, RD
Local anesthetics
Lidoderm lidocaine patch CE
Mexilitene lidocaine derivative-oral CE
Anti-hypertensive for relief of nerve pain
Catapres TTS clonidine patch LB
Table 2 - Various types of medication that act directly near the site of injury or irritation to block the generation or transmission of the pain information.

All pain medications listed in the text and table of this site have side effects. In addition to those listed as special risks for each of these medications, there are serious but unusual side effects that occur rarely such as decreased production of blood cells by the body. All medications are risky for anyone who may be pregnant or who is breast feeding and require special attention before prescribing. With the exception of over-the-counter drugs, all of these medications should only be taken with a prescription for the patient and under the direction of a physician. Liver toxicity and kidney toxicity usually do not occur, but routine blood tests for signs of these problem are essential if they are taken on an ongoing basis.


(A1) – some addiction potential; (CE) – cardiac effects; (DI) – dizziness; (DR) – drowsiness; (GI) – gastric irritation;  (LB) - low blood pressure; (LT) – liver toxicity; (MC) – mental clouding; (RD) - respiratory depression; (WI) – withdrawal risk.