But erythropoietin – this is not only beneficial, but also a side effect: it causes an increased intake of vitamin B12, copper, iron and folate by the bone marrow, which leads to a deficiency of these microelements, as well as to the degradation of ferritin and transcobalamin, – transport proteins.
Other potential side effects of erythropoietin: high blood pressure, increased blood viscosity, dizziness, headache, confusion, skin rash and some others (which are manifested mainly with drug abuse and / or individual predisposition).
Packaging:injection (3000 IU)
Box and instructions:in stock (with each injection)
Keep:in the refrigerator (2-8 degrees °C)
Recombinant Human Erythropoietin Injection (Canada Peptides) – it is a hormonal preparation designed for injection use. As a sports doping, it is effective and is used as a stimulant of endurance: to increase strength, increase efficiency and prevent overtraining.
INJECTION OF RECOMBINANT HUMAN ERYTHROPOETIN: PROPERTIES
The drug has an active active substance of the same name, – erythropoietin. It is one of the kidney hormones (also secreted in the perisinusoidal cells of the liver) that controls erythropoiesis (the process of formation of red blood cells, – red blood cells). In terms of chemical structure, it is a glycoprotein. Used in medicine as a hormonal medication, in sports – like hormonal doping.
Erythropoietin – it is a physiological stimulant of erythropoiesis (one of the varieties of hematopoiesis, – hematopoiesis). In the human body, it is produced mainly by the kidneys (renal production prevails in adulthood) and partly by the liver (hepatic production predominates in the embryonic and perinatal periods). The mechanism of action of EPO (abbreviated name) is tied to the activation of mitosis and the maturation of erythrocytes from progenitor cells. Its renal secretion increases with: ischemia of the kidneys, hypoxic conditions, anemic conditions and blood loss.
Erythropoietin (EPO) is also intensively produced under the influence of glucocorticoids, which in stressful situations is one of the ways to urgently increase the level of hemoglobin and improve the oxygen-supplying capacity of the blood. Hemoglobin and red blood cells, as a rule, increase several hours after drug administration.
cycle OF INJECTION OF RECOMBINANT HUMAN ERYTHROPOETIN
It is known that injectable Recombinant Human Erythropoietin, Like its natural counterpart, it acts by interacting with EpoR receptors (erythropoietin receptors): by binding to them, EPO triggers JAK2 (Janus kinase 2) signaling cascades.
The use of erythropoietin, as a rule, is carried out subcutaneously (but in medicine, intravenous infusion is allowed). The hormone is highly glycosylated (≈ up to 40% of the total molecular weight), and the half-life is ≈ 5 hours (but half-life varies and is higher for recombinant forms ≈ 5+ hours).
In sports, erythropoietin injections are unofficially used to stimulate endurance (considered effective in athletics, and not only, disciplines, – from walking to muay thai). The ability of a person’s muscles to withstand endurance exercises is largely dependent on the supply of oxygen to them. This is why EPO is in high demand among amateurs and sports professionals.
In medicine, in turn, a cycle of erythropoietin is prescribed to correct anemia in diseases caused or accompanied by it: chronic renal failure, chronic inflammatory bowel diseases, chronic infectious diseases, HIV infection. Also, indications for use may be: organ and tissue transplantation, auto donation, refusal of transfusion of allogeneic hemocomponents and general weakness (in the elderly, premature babies, etc.).
The dosage of erythropoietin is set individually (in accordance with the tasks and tolerance of the particular user). The same applies to the schedule / duration of injections. In sports, the cycle is recommended to start with a minimum amount of substances in order to determine the susceptibility of the organism, and then gradually increase the volumes to determine the individually working dose. In medicine, the initial doses do not exceed 50-150 IU / kg with the frequency of administration 3 times a week.